INTRA-ARTICULAR IGF-1 IN SEVERE OSTEOARTHRITIS OF KNEE

$0M01FY2000RRNIH

University Of California San Francisco, San Francisco CA

Investigators

Linked publications & trials

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Abstract

These investigators will study the effect of IGF-1 on patients with osteoarthritis of the knee of sufficient severity to require a knee joint replacement. Patients will undergo a knee arthroscopy and cartilage biopsies, and then will be randomized to receive either IGF-1 or placebo by intra-articular injections. After the injections end, the patient will have joint replacement. The GCRC will be utilized for the injections by the PI and phlebotomy by the nursing staff.

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