SAFETY, TOLERANCE, PHARMACOKINETICS, AND ANTIVIRAL ACTIVITY OF PMPA IN HIV

$564M01FY2000RRNIH

University Of California San Francisco, San Francisco CA

Investigators

Linked publications & trials

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Abstract

The purpose of this study is to evaluate the safety and pharmacokinetics of single and multiple doses of PMPA pro-drug administered orally to HIV-infected patients and to evaluate the anti-HIV activity of PMPA pro-drug, as demonstrated by increases in CD4 cell counts and decreases in HIV RNA, when administered orally as a single dose and daily for four weeks to HIV-infected patients with CD4 cell counts >200 cells/mm3.

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