METABOLISM AND CLEARANCE OF NICOTINE IN PREGNANT WOMEN

$564M01FY2000RRNIH

University Of California San Francisco, San Francisco CA

Investigators

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Abstract

The specific aims of this study are to determine: (1) metabolic renal clearance of nicotine and cotinine; (2) the plasma half-life of nicotine and cotinine; (3) fractional conversion of nicotine to cotinine; and (4) pattern of nicotine metabolism in pregnant women. Investigators will also determine alterations in tobacco use (nicotine intake) that may occur during pregnancy.

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