STABLE ISOTOPE STUDIES OF NICOTINE AND COTININE METABOLISM

$564M01FY2000RRNIH

University Of California San Francisco, San Francisco CA

Investigators

Linked publications & trials

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Abstract

This protocol compares the disposition kinetics of natural (unlabeled cotinine) and deuterium-labeled cotinine; compares the rates of metabolism of deuterium-labeled nicotine and low doses in smokers and non-smokers; and studies the pharmacokinetics of nicotine and cotinine, making use of a combined infusion of labeled compounds in subjects of different ages and gender.

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