GV150526 IN TREATMENT OF ACUTE STROKE

$19,199M01FY2000RRNIH

Case Western Reserve University, Cleveland OH

Investigators

Linked publications & trials

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Abstract

This is a multicenter randomized double-blind placebo controlled parallel group study evaluating the efficacy and safety of GC150526 or placebo in patients with a clinical diagnosis of acute stroke. This drug is a potent glycine antagonist. Glycine is a co-agonist of the NMDA receptor for glutamine-induced and neuroexcitation. Since this NMDA receptor by stimulation of this NMDA receptor by glutamate may be cytotoxic during cerebral ischemia, antagonism of this receptor may be beneficial.

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