9 AC COLLOIDAL DISPERSION INFUSION IN ADVANCED NON SMALL CELL LUNG CA

$19,199M01FY2000RRNIH

Case Western Reserve University, Cleveland OH

Investigators

Linked publications & trials

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Abstract

The objectives of this trial are to: To determine if 9-aminocamptothecin CD administered as a 120h weekly infusion is an effective agent of treatment of advanced non-small cell lung cancer. To observe the toxicity associated with this regimen among patients with advanced nonsmall cell lung cancer. To measure the levels of topoisomerase I in tumor biopsy specimens obtained from patients with non small cell lung cancer entered on this trial. To determine the 9-AC pharmacokinetics parameters and to correlate serum levels with toxicity and response to treatment. To determine the mutagenic potential of 9-AC administered as a 120hr weekly infusion."

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