Trial of irinotecan (CPT-11) in recurrent malignant glio

$0M01FY2000RRNIH

University Of California San Francisco, San Francisco CA

Investigators

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Abstract

The goals of this study are the following: (1) To determine the maximum tolerated dose of CPT-11 when administered every 3 weeks to patients with recurrent malignant glioma. (2) To determine toxicities of every three-week dosing. (3) To characterize pharmacokinetics of CPT-11 and its metabolites, SN-38, SN-38 gluconide (SN-38G) and APC. (4) To assess antitumor activity. We wish to use the expertise of the GCRC in drug administration, patient care, and patient teaching to achieve the study goals.

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