NABTC 9702--PHASE I TRIAL OF PRESURGICAL 06-BENZYLGUANINE

$0M01FY2000RRNIH

University Of California San Francisco, San Francisco CA

Investigators

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Abstract

In the presence of O6-Benzylguanine (06-BG) tumor cell lines have demonstrated an increased sensitivity to alkylating agents such as nitrosoureas and procarbazine. The mechanism proposed for this property of O6-BG is in part attributed to its ability to inactivate an important enzyme involved in DNA replication and repair pathways called alkylguanine-DNA alkyltransferase (AGT). The objectives of the study are the following: (1) To define a dose of O6-BG that depletes all AGT activity in >90% of the AA or GM cases evaluated. (2) To evaluate the associated toxicities both quantitatively and qualitatively. GCRC expertise would be used to administer the pre-surgical O6-BG administration and subsequently to provide consistent data with daily blood draws and toxicity notation.

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