STUDY OF ORAL LOBUCAVIR IN PATIENTS WITH RECURRENT GENITAL HERPES

$34,211M01FY2000RRNIH

University Of Texas Medical Br Galveston, Galveston TX

Investigators

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Abstract

We will test the efficacy and safety of a new antiviral drug, lobucavir, from Bristol Myers Squibb, in immunocompetent subjects with recurrent genital herpes infections. Volunteers in this randomized, double-blind, placebo-controlled study will receive one of three doses of lobucavir or placebo twice daily for five days. Follow-up visits to the clinic will continue until the genital herpes lesions are completely healed. Lobucavir has proven a potent antiviral in tissue culture and animal model studies. Therefore, the findings from these studies may help in developing a genital herpes treatment that will hasten healing of lesions and reduce the severity or duration of the pain and discomfort associated with the infection.

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