INSULIN HPN &REGULAR PREMIX RATIO 50 &50 VS PREMIX RATIOS 70 &30

$3,034M01FY2000RRNIH

University Of Pittsburgh At Pittsburgh, Pittsburgh PA

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Abstract

The specific objective of this study is to demonstrate that insulin 50/50 (NPH/R) is different from insulin 70/30 (NPH/R) as measured by the total amount of glucose infused during the first four hours after injection. This study will investigate differences between a premixed insulin preparation containing 5 units NPH for every 5 units regular insulin (50/50) and a (70/30) insulin preparation. Two 12 hour euglycemic clamp procedures will be performed in healthy men. Subjects will receive 0.2 units subcutaneously of the 50/50 or 70/30 insulin preparation in a blinded manner. Twenty percent dextrose will be infused at a dose titrated to maintain euglycemia. The primary efficacy measure will be the difference in glucose infusion rates required to maintain euglycemia during the first 4 hours after injection.

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