PHARMACOKINETICS OF ABT-627 IN SUBJECTS WITH REFRACTORY MALIGNANCIES

$0M01FY2000RRNIH

University Of Chicago, Chicago IL

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Abstract

ABT-627 is an oral antagonist of the endothelial receptor Eta, and may paliate bone pain by inhibiting ET-1 activity and may retard progression of cancer by inhibiting ET-1 induced growth factors. The objective of this study is to evaluate the safety, tolerability, and pharmacokinetics of chronic daily oral administration of ABT-627.

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