MAGE-3 PLUS IL-12 IMMUNIZATION IN METASTATIC MELANOMA

$0M01FY2000RRNIH

University Of Chicago, Chicago IL

Investigators

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Abstract

Tumor antigen-specific immunotherapy of melanoma patients will be investigated. The patients will be HLA-typed and their tumors biopsied to analyze for MAGE-3 expression. If eligible, PBMC will be isolated and pulsed with the relevant MAGE-3 peptide. These will be washed and injected subcutaneously into the patient, along with rhIL-12. Safely, immune parameters, and tumor response will be monitored.

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