IV MNTX GUT EFFECT IN CHRONIC METHADONE THERAPY AND CHRONIC PAIN PATIENTS

$0M01FY2000RRNIH

University Of Chicago, Chicago IL

Investigators

Linked publications & trials

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Abstract

(1) To test the hypothesis that IV methylnaltrexone can be safely used in reversing methadone-induced gastrointestinal motility changes without withdrawal symptoms in subjects receiving chronic methadone therapy. (2) To test the hypothesis that IV methylnaltrexone can be used in treatment (or prevention) of opioid-induced constipation without interfering with analgesia in chronic patients with metastatic malignancy.

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