GENETICS OF INSULIN SECRETION AND RESISTANCE IN POLYCYSTIC OVARY SYNDROME

$0M01FY2000RRNIH

University Of Chicago, Chicago IL

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Abstract

This study seeks to determine 1) if beta cell secretory dysfunction is more prevalent among insulin resistant women with PCOS compared to similarity insulin resistant controls; 2) if first-degree relatives of women with PCOS are at increased risk of a) IGT or NIDDM; b) insulin resistance; c) beta cell secretory dysfunction. We also seek to a) characterize the transmission of beta cell function and insulin sensitivity in families of women with PCOS; b) determine whether the transmission of insulin sensitivity is independent of the transmission of beta cell function; c) characterize the extent to which beta cell dysfunction contributes to the risk imparted by insulin resistance to the development of NIDDM.

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