EFFECTS OF ETHNICITY ON CYTOCHROME P450 IN HLTHY INDIVS USING MIDAZOLAM

$42,739M01FY2000RRNIH

Tufts Medical Center, Boston MA

Investigators

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Abstract

There is little available data on the effects of ethnicity on drug disposition. Understanding the activity of the cytochrome P450 3A4 enzyme (CYP3A4) is important to the metabolism of a wide variety of xenobiotics. Midazolam has recently been studied as an attractive in vivo probe for CYP3A4. The pharmacokinetics of oral and intravenous midazolam will be studied in twenty-four healthy African-American and Caucasian individuals.

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