MECHANISM OF INCREASED PLASMA APO A1 LEVELS BY ESTROGENS

$42,739M01FY2000RRNIH

Tufts Medical Center, Boston MA

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Abstract

Postmenopausal women are at higher risk of coronary heart disease (CHD) than premenopausal women, even after controlling for age-effects. However, estrogen replacement therapy significantly lowers the risk of CHD in postmenopausal women. With this study, we propose to determine the kinetics of apolipoprotein A-I, the major protein component of high density lipoproteins, in postmenopausal women undergoing a placebo-controlled, randomized treatment with each of the following regimens:a)placebo,b)0.625mg/d conjugated estrogens, and c)0.625mg/d conjugated estrogens.

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