PHENYLBUTYRATE &MUCOCILIARY CLEARANCE IN CYSTIC FIBROSIS

$0M01FY2000RRNIH

Johns Hopkins University, Baltimore MD

Investigators

Linked publications & trials

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Abstract

This is a randomized, placebo-controlled, double blind crossover trial in 10CF patients of the effects of phynylbutyrate on pulmonary mucociliary clearance (MCC). The aim is to quantify and compare the rate of MCC on study drug and placebo. Patients will take a standard dose three times a day for one month separated by a month of washout. Radiotracer MCC, nasal potential differences, and sweat chlorides will be measured.

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