Stem Cell Biology And Brain Disease

Neurological Disorders And Stroke

Investigators

Linked publications & trials

Abstract

Work in LMB has led the way towards the ambitious goal where stem cells can be used to replace tissue damaged by neurodegenerative diseases that cause the loss of neurons or glial cells. We have previously demonstrated that stem cells derived from the fetal brain can generate neurons that secrete the neurotransmitter dopamine but these cells can provide unlimited numbers of these neurons. In the last year we have continued to develop embryonic stem (ES) cells as a source of dopamine neurons. These are the type of neuron lacking in Parkinson's patients and these neurons have not previously been obtained in such large numbers. Parkinson's disease (PD) is a widespread neurological condition caused by the loss of neurons in the midbrain that synthesize the transmitter dopamine. Clinical experience suggests that cells derived from the fetal midbrain can modify the course of the disease. The limited supply of this tissue may be overcome by new stem cell technologies. Precursors from the fetal brain are not an adequate source of these neurons because their ability to generate dopamine neurons is not stable. In contrast, embryonic stem (ES) cells proliferate extensively and generate dopamine-synthesizing neurons that show electrophysiological and behavioral properties expected of neurons from the midbrain. These results were obtained with mouse ES cells but recent work from our group suggests that human ES cell differentiation to dopamine neuron fates.