Updating Risks and Benefits in Phase I Oncology Trials

Clinical Center

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Abstract

This study is a meta-analysis of the responses and toxic death rates of all phase I oncology studies initiated between 1991 and 2002 and sponsored by CTEP/NCI. The goal is to update our understanding of responses and toxicities in Phase I oncology trials. A second goal is to describe the diversity of phase I oncology trials and to show that relying on a single value to understand response or toxicity is misleading.