PHARMACOKINETICS OF GENISTEIN, TYROSINE KINASE INHIBITOR

$0M01FY2000RRNIH

Northwestern University, Evanston IL

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Abstract

The primary objectives of this study are to determine pharmacokinetic parameters of two preparations of genistein (i.e. a 43% genistein preparation and a 90% genistein preparation) in humans and to determine toxicity of each preparation when administered as a single dose. The secondary objectives are to determine effects of a single dose of genistein on phosphotyrosine levels in peripheral mononuclear cells and to determine relative bio-availability of two preparations of genistein in humans.

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