Genetic risk profile in longitudinal systemic lupus erythematoses

$0M01FY2000RRNIH

Northwestern University, Evanston IL

Investigators

Linked publications & trials

Paper 34627374 Paper 31870756 Paper 30081088 Paper 27931290 Paper 27742085 Paper 27421900 Paper 26761271 Paper 26745754 Paper 26715195 Paper 25896533 Paper 25564820 Paper 25379191 Paper 25075114 Paper 25029420 Paper 24376005 Paper 23990511 Paper 23959159 Paper 23946713 Paper 23827400 Paper 23500321 Paper 23352363 Paper 23099133 Paper 22956269 Paper 22885850 Paper 22608041 Paper 22479352 Paper 22440216 Paper 22362335 Paper 22357187 Paper 22355019 Paper 22314392 Paper 22301123 Paper 22190480 Paper 22180642 Paper 22178088 Paper 22091499 Paper 22088620 Paper 21885884 Paper 21784434 Paper 21727914 Paper 21636676 Paper 21636037 Paper 21546831 Paper 21444075 Paper 21378253 Paper 21371679 Paper 21292130 Paper 21283731 Paper 21252242 Paper 21245576 Paper 21178773 Paper 21078733 Paper 20861747 Paper 20843942 Paper 20819961 Paper 20813580 Paper 20706608 Paper 20633400 Paper 20598471 Paper 20588104 Paper 20550604 Paper 20535799 Paper 20511294 Paper 20510967 Paper 20434061 Paper 20403491 Paper 20207245 Paper 20200332 Paper 20164352 Paper 20160950 Paper 20160152 Paper 20089115 Paper 20059445 Paper 20038853 Paper 19837913 Paper 19825958 Paper 19796772 Paper 19790113 Paper 19762396 Paper 19738138 Paper 19686155 Paper 19648255 Paper 19644854 Paper 19625733 Paper 19596010 Paper 19529994 Paper 19525382 Paper 19401371 Paper 19359262 Paper 19351735 Paper 19325470 Paper 19298919 Paper 19188877 Paper 19187334 Paper 19141764 Paper 19138649 Paper 19135238 Paper 19132787 Paper 19059160 Paper 19016802

Abstract

The three aims of the research study are: 1) Establish a multicenter common core database of systemic lupus erythematosus (SLE) patients from multiple ethnicities (profile cohorts) comprised of established patients who are already in local cohorts as well as new patients to be recruited; 2) Assess the ability of chromosome 1 genes (q21-32) to predict disease phenotype [renal,cardiovascular, pulmonary, and central nervous system (CNS) involvement] in this profile cohort of SLE patients; and 3) Establish a core set of trio to confirm and narrow the identification of candidate regions and genes in SLE. The first two goals will be accomplished through a longitudinal study of 700 SLE patients. The third goal will be accomplished through a study on 350 trio families (lupus patients and both biological patients). These aims will serve to create the largest number of lupus patients in whom meticulously gathered data will be available to study the genetics of lupus and the relative contributions of genetics (versus other factors) to disease phenotype. The Chicago cohort aims to provide the Specialized Center of Research in SLE (SCOR) study with 175 PROFILE patients adn 50 TRIO families.

View original record on NIH RePORTER →