METYRAPONE CHALLENGE IN MAJOR DEPRESSION

$0M01FY2000RRNIH

Weill Medical College Of Cornell Univ, New York NY

Investigators

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Abstract

The hypothalamic-pituitary-adrenal (HPA) axis is activated in patients with major depression. The primary hypothesis of this study is that HPA axis activity will be relatively reduced in women with the atypical subtype of depression compared to women with melancholic depression. HPA axis activation will be assessed by measuring the ACTH responses to metyrapone.

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