DDL/D4T/HU VS DDL/D4T/EFV VS PROTEASE INHIBITOR IN HIV PTS

$0M01FY2000RRNIH

University Of North Carolina Chapel Hill, Chapel Hill NC

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Abstract

ACTG 5039: The primary objectives are: 1) To obtain preliminary data regarding the rates of maintained viral suppression in subjects randomized to ddl/d4T/HU (Arm A) and ddl/d4T/EFV (Arm B) compared to continued therapy with protease inhibitor-containing regimen (Arm C); 2) To compare the frequency of toxicity and treatment intolerance on all three arms; and 3) To obtain preliminary data regarding the rate at which viral suppression can be achieved and maintained with re-initiation of the pre-empty regimen following virologic failure in Arm A or B compared to the rate of maintained viral suppression in Arm C.

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