EFFEC OF A-100 ON GLYCEMIC CONTROL IN OVERWEIGHT NIDDM

$0M01FY2000RRNIH

University Of North Carolina Chapel Hill, Chapel Hill NC

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Abstract

The purpose of this Phase II study is to test how well A-100, a man made form of a naturally occuring hormone called Leptin, works in controlling blood sugar levels in overweight people with type 2 diabetes and to determine how safe the drug is compared to a placebo. Leptin is made in fat cells and is believed to be involved in controlling blood sugar and body weight. A-100 may work by increasing the body's response to insulin and it may cause some weight loss. Both results would be expected to give patients better blood sugar control.

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