METASTASIS SUPPRESSOR GENE KA11 IN PROSTATE CANCER

$0M01FY2000RRNIH

University Of North Carolina Chapel Hill, Chapel Hill NC

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Abstract

The purpose of this study is to define the metastatic suppressor role of KAI1 in prostate cancer (CAP). We hypothesize that: (Specific aim 1) KAI1 is a predictive molecular marker of metastasis and therefore a prognostic indicator in prostate cancer patients; (2) KAI1 is downregulated in prostatic intraepithelial neoplasia (PIN), the purported precursor to CaP; (3) KAI1 is involved in the transition of androgen-dependent to androgen-independent CaP; and (4) KAI1 exerts its suppressive activity at several points during the metastatic cascade.

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