NEFAZODONE ON HYPOTHALAMIC-PITUITARY ADRENAL AXIS

$0M01FY2000RRNIH

University Of North Carolina Chapel Hill, Chapel Hill NC

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Abstract

The purpose of this study is to assess the effect of nefazodone on the HPA axis dynamics as measured by cortisol and ACTH at baseline and after a single IV dose of methylprednisolone in normal volunteers. 2) Investigate the effect of nefazodone on noradrenergic, serotonergic, and platelet parameters in healthy adults in order to gain a preliminary understanding of the effect that nefazodone might have in medically compromised individuals with coronary artery disease or other illness in which adrenergic, serotonergic, or platelet parameters might influence prognosis.

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