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HIVIG MATERNAL FETAL TRANSMISSION IN PREGNANT WOMEN AND NEWBORNS

$0M01FY2000RRNIH

University Of North Carolina Chapel Hill, Chapel Hill NC

Investigators

Linked publications & trials

Abstract

ACTG 185: To evaluate the effect of polyclonal HIV immune globulin in the prevention of perinatal HIV transmission if given in combination with antepartum, intrapartum (mother) and postpartum (infant) zidovudine, beginning at 20-30 wks. gestation at monthly intervals. It is anticipated that provision of antiviral antibody in the HIV-infected pregnant woman and the newborn within 12 hours of delivery may neutralize circulating infections HIV, and thereby presumably reduce or prevent transplacental and/or peripartum HIV infection of fetus/infant.

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