STUDIES OF PHARMACOLOGIC EFFECT OF L-ASPARAGINASE

$14,791M01FY2000RRNIH

University Of Rochester, Rochester NY

Investigators

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Abstract

To compare the anti-leukemia efficacy, acture toxicity and biochemical pharmacology of E. coli, Erwinia, adn PEG-modified E. coli ASP at the Investigational window in all patients. L-asparaginase has become a vital componet in the treatment of children with acute lymphoblastic leukemia. The antileukemic activity of ASNase is thought to result from depletion of serum asparagine.

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