PHASE I STUDY OF TAXOTERE IN PATIENTS WITH ADVANCED MALIGNANCIES

$35,553M01FY2000RRNIH

University Of Southern California, Los Angeles CA

Investigators

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Abstract

There are 3 objectives to study: 1) To establish the MTD of taxotere in patients with varying degrees of liver dysfunction (mild, moderate and severe); 2) To determine the effects of hepatic dysfunction on the plasma pharmacokinetics and pharmacodynamics of taxotere; 3) To study the utility of indocyanine green clear nace and lidocaine matabolism as indicators of taxotere hapatic elimation. Taxotere is an naolog of taxol. It will be administered every three weeks at varying levels depending on hepatice dysfunction.

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