TRANSDUCTION OF CD34+ CELLS FROM THE BONE MARROW OF HIV-1 INFECTED CHILDREN
$35,553M01FY2000RRNIH
University Of Southern California, Los Angeles CA
Investigators
Linked publications & trials
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Abstract
Gene Therapy may provide a new therapeutic approach to pediatric AIDS. The central hypothesis is that a gene encoding an anti-HIV RNA molecules (an RRE decoy) can be inserted into CD34+ cells from bone marrow of HIV-1 infected children leading to production of mature T cells and monocytes which express the anti-HIV gene and are thereby resistant to HIV-1 replication.
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