PHASE II RANDOMIZED STUDY OF PACLITAXEL VS PACLITAXEL+PSC833 FOR BREAST CANCER

$35,553M01FY2000RRNIH

University Of Southern California, Los Angeles CA

Investigators

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Abstract

To evaluate the response rate, time to treatment failure, and pharmacokinetics of paclitaxel (Taxol) with and without PSC 833 (a cyclosporin analogue which is active in reversing multidrug resistance gene expression in cancer cells) in advanced hormonally-insensitive breast cancer subjects.

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