EFFECT OF TROGLITAZONE ON CYP 3A4 &ON DEXAMETHASONE SUPPRESSION TEST

$206M01FY2000RRNIH

University Of Michigan At Ann Arbor, Ann Arbor MI

Investigators

Linked publications, trials & patents

Paper 38314748 Paper 38198070 Paper 37685568 Paper 37330506 Paper 37234789 Paper 36609358 Paper 35776183 Paper 34096894 Paper 33560208 Paper 33002231 Paper 32980045 Paper 32603751 Paper 31505070 Paper 31404238 Paper 31282733 Paper 31190621 Paper 30984083 Paper 30927986 Paper 30747308 Paper 30678194 Paper 30557093 Paper 29993318 Paper 29212847 Paper 28960081 Paper 28869987 Paper 28643023 Paper 28451964 Paper 28122876 Paper 27979912 Paper 27943008 Paper 27549341 Paper 27542969 Paper 27434583 Paper 27420606 Paper 27335285 Paper 27142670 Paper 27009936 Paper 26908360 Paper 26597192 Paper 26536870 Paper 26456676 Paper 26346867 Paper 26313512 Paper 26030112 Paper 25794949 Paper 25643011 Paper 25419511 Paper 25401485 Paper 25139294 Paper 25037617 Paper 24956500 Paper 24920421 Paper 24802413 Paper 24760534 Paper 24729646 Paper 24656865 Paper 24613295 Paper 24524706 Paper 24516231 Paper 24448547 Paper 24415732 Paper 24409005 Paper 24219913 Paper 24218993 Paper 24104772 Paper 24084768 Paper 24077027 Paper 24066347 Paper 24008570 Paper 23923994 Paper 23727086 Paper 23572495 Paper 23559261 Paper 23546553 Paper 23530302 Paper 23489677 Paper 23445216 Paper 23377559 Paper 23362085 Paper 23344473 Paper 23321443 Paper 23298715 Paper 23291148 Paper 23282046 Paper 23222413 Paper 23178053 Paper 23090351 Paper 23076013 Trial NCT00006434 Trial NCT00006332 Trial NCT00006331 Trial NCT00006330 Trial NCT00006329 Trial NCT00006328 Trial NCT00005667 Trial NCT00005666 Trial NCT00004564 Trial NCT00000111 Trial NCT00000108 Patent 7996076

Abstract

We have recently identified a patient who had a false positive low dose dexamethasone suppression test (DST) that likely resulted from treatment with a new insulin sensitizing agent, troglitazone (Rezulin). Data from clinical studies suggest that troglitazone induces hepatic CYP3A4, the most prevalent drug metabolizing enzyme in the liver and the enzyme that is also responsible for the metabolism of dexamethasone. We suggest that as troglitazone becomes more frequently used and as its indications for use broaden, false positive DST in patients treated with troglitazone will become common. The proposed investigations will establish whether troglitazone does alter DST via an increase in CYP3A4 activity.

View original record on NIH RePORTER →