ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIA
$217,500R01FY2003HLNIH
Louisiana State Univ Hsc Shreveport, Shreveport LA
Investigators
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Abstract
DESCRIPTION: (Adapted from the Investigator's Abstract): The researchers will 1) demonstrate the altered epithelial integrity associated with preeclampsia that is characterized by diminished barrier function and increase intracellular permeability; 2) determine how placenta-derived factors mediate the epithelial barrier dysfunction of preeclampsia; and 3) identify the cellular mediators that are responsible for the altered endothelial integrity mediated by placental factors in preeclampsia.
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