IMMUNOTHERAPY OF MALIGNACY BY IN VIVO GENE TRANSFER INTO TUMORS

$0M01FY2000RRNIH

University Of Michigan At Ann Arbor, Ann Arbor MI

Investigators

Linked publications & trials

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Abstract

In this study we propose to test the safety and efficacy of an experimental therapy designed to induce regression of tumors that are currently incurable. This will be accomplished by the delivery, directly into the tumor, of a DNA/liposome complex that directs the synthesis of histocompatibility antigen B7. This protein, when expressed on the surface of the tumor, stimulates immune rejection of the malignant tissue.

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