UPCC 5598: GENE THERAPY OF MALIGNANT MESOTHELIOMA USING EL/E4 DELETED ADENOVIRUS

$0M01FY2000RRNIH

University Of Pennsylvania, Philadelphia PA

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Abstract

The purpose of this amended Phase I study will be to evaluate the safety and toxicity of escalating doses of intravenous ganciclovir (GCV) coupled with intrapleural delivery of a "third generation" El/E4-deleted adenoviral vector expressing the Herpes Simplex Thymidine kinase (HSVtk) gene to treat patients with inoperable malignant mesothelioma. This study is a logical extension of our past and present Phase l studies evaluating the safety and toxicity of escalating doses of intrapleural recombinant adenoviral-HSV tk vector in combination with intravenous GCV to treat patients with mesothelioma.

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