RENIN, SODIUM INTAKE, AND INSULIN SENSITIVITY

$0M01FY2000RRNIH

University Of Pennsylvania, Philadelphia PA

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Abstract

This protocol evaluates the effects of a high (>200 meq/d) versus a low (20 me1/d) sodium diet on the ability of insulin to promote glucoe uptake during euglycemic clamp conditions pursuing the hypothesis that a high salt intake suppresses both renin and sympathetic actaivity leading to a greater skeletal muscle blood flow and increased insulin sensitivity. Also, high salt diet raise plasma free fatty acid (FFA) concentrations, and we have incorporated studies using a s table isotope of glycerol to evaluate the role of changes in lipolysis on the different salt diets as the cause of increased FFA.

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