UPCC #1698 INJECTIONS OF B7 1 IN PATIENTS W/ METASTATIC MELANOMA

$25,114M01FY2000RRNIH

University Of Pennsylvania, Philadelphia PA

Investigators

Linked publications & trials

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Abstract

The objectives of this study are to: assess the local and systemic toxicity (the maximum tolerated dose) associated with the in vivo B7-1 gene transduction (intratumoral injection) in patients with metastatic melonoma and metastatic breast cancer; assess the local and systemic immunomodulatory effects of intratumoral B7-1 administration; seek preliminary evidence of therapeutic activity of this therapy.

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