ACTG A5047:Pharmacokinetic interactions with protease inhibitors &lipid lowering

$0M01FY2000RRNIH

Washington University, Saint Louis MO

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Abstract

Investigate the effect of ritonavir (RTV) and saquinavir (SQV) on the pharmacokinetics of pravastatin, simvastatin, and atorvastatin. Evaluate the effect of pravastatin on the dispostion of nelfinavir and its M8 metabolite.

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