R METHU FC LEPTIN/R METHULEPTIN ON GLUCOSE AND LIPID METABOLISM IN NIDDM

$0M01FY2000RRNIH

Washington University, Saint Louis MO

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Abstract

This study will evaluate the effect of leptin on glucose and lipid metabolism in patient with Type 2 Diabetes Mellitus. Thirty subjects will be randomized to recieve Leptin, Fc-Leptin, or Placebo for 14 days. Glucose and lipid kinetics during basal conditions and a 2 stage hyperinsulinemic euglycemic clamp will be determined before and after treatment.

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