ALPHA 1 ANTITRYPSIN DEFICIENCY--GENOTYPE/PHENOTYPE STUDIES

$0M01FY2000RRNIH

Washington University, Saint Louis MO

Investigators

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Abstract

A subset of homozygous PiZZ alpha1-AT-deficient individuals is more susceptible to liver injury by virtue of a second inherited traits, or facts which exaggerates the intracellular accumulation of mutant alpha1-AT, or exaggerates the cellular pathophysiologic consequences of mutant alpha1-AT accumulation. Identification of this trait or traits may allow predictive testing for susceptibility to liver disease as well as novel approaches for pharmacologic amelioration of the liver injury.

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