TAXOTERE W/ CONTINUOUS INFUSION TOPOTECAN IN ADVANCED MALIGNANCIES

$29,529M01FY2000RRNIH

University Of Alabama At Birmingham, Birmingham AL

Investigators

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Abstract

Phase I study of two cytotoxic chemo agents which have broad spectrum of activity and non-cumulative myelosuppression. Toxicities to date have been fever + neutropenia occurring in 3 patients grade 3 neuropenia in ~ 50% of patients receiving at lease 1 cycle grade 2 asthenia in 6 patients. No objective responses.

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