PNU 214936 IN ADVANCED NON SMALL CELL LUNG CANCER

$29,529M01FY2000RRNIH

University Of Alabama At Birmingham, Birmingham AL

Investigators

Linked publications & trials

Paper 37930135 Paper 37717845 Paper 36732048 Paper 35895739 Paper 35728925 Paper 35105718 Paper 35073533 Paper 34459249 Paper 33478957 Paper 32446491 Paper 32324809 Paper 32111975 Paper 31691959 Paper 31171572 Paper 31107800 Paper 31099252 Paper 31088850 Paper 30922668 Paper 30737489 Paper 30711733 Paper 30704533 Paper 30704471 Paper 30696834 Paper 30673733 Paper 30670697 Paper 30644068 Paper 30643923 Paper 30633135 Paper 30631138 Paper 30630856 Paper 30620636 Paper 30616455 Paper 30611756 Paper 30604092 Paper 30591655 Paper 30591038 Paper 30579893 Paper 30550514 Paper 30518827 Paper 30390872 Paper 30373734 Paper 30348535 Paper 30316957 Paper 30283153 Paper 30253082 Paper 30239453 Paper 30098512 Paper 30019375 Paper 29988125 Paper 29966428 Paper 29957829 Paper 29872859 Paper 29852236 Paper 29844224 Paper 29601997 Paper 29573242 Paper 29490097 Paper 29476611 Paper 29377636 Paper 29352962 Paper 29305129 Paper 29290310 Paper 29101219 Paper 29053861 Paper 29042080 Paper 29037052 Paper 29019707 Paper 28963767 Paper 28849323 Paper 28783458 Paper 28647272 Paper 28595362 Paper 28532709 Paper 28490543 Paper 28390007 Paper 28283553 Paper 28281179 Paper 28214041 Paper 28199816 Paper 28074138 Paper 28027795 Paper 27984407 Paper 27827322 Paper 27779124 Paper 27665490 Paper 27660033 Paper 27455401 Paper 27423510 Paper 27195603 Paper 27074126 Paper 26797708 Paper 26771691 Paper 26515780 Paper 26278503 Paper 26269238 Paper 26080344 Paper 25990704 Paper 25884953 Paper 25738669 Paper 25459782

Abstract

This is an open-label, phase I study of a recombinant fusion protein (mutated SEA superantigen linked to Fab fragment recognizing a tumor-associated glycoprotein 5T4) [unreadable] PNU-214936 in patients with advanced non-small cell lung cancer. Primary side effects of PNU214936 observed, included transitory hypertensive episodes, fever/chills and fatigue (most frequent side effects). The primary objective of this study is to determine the MTD of PNU-214936 as a function of pretreatment anti-SEA antibody levels by giving infusions for 4 consecutive days in patients with advanced NSCLC. Secondary objectives includes safety profile, tumor response, immunological response and pharmacokinetic parameters.

View original record on NIH RePORTER →