MECHANISMS OF ANTIFOLATE EFFICACY

$29,529M01FY2000RRNIH

University Of Alabama At Birmingham, Birmingham AL

Investigators

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Abstract

This is a double-blind trial to evaluate the hypothesis that the beneficial effect of low-dose Methotrexate therapy in rheumatoid arthritis is due to the inhibition of aminoimidazole-carboxamide-ribotide transformylase, a folate-dependent enzyme which catalyzes the last step in the de novo biosynthesis of inosine monophosphate. Patients are supplemented in double-blindfashion with either folic and or folinic acid in a double-blind fashion and urinary levels of aminoimidazole carboxamide and adenosine are monitored.

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