MECHANICAL PROPERTIES OF WHITE BLOOD CELLS

$0M01FY2000RRNIH

Duke University, Durham NC

Investigators

Linked publications & trials

Paper 35728925 Paper 33478957 Paper 32111975 Paper 31691959 Paper 31427096 Paper 30737489 Paper 30631138 Paper 29872859 Paper 28647272 Paper 28283553 Paper 28199816 Paper 27917299 Paper 27455401 Paper 27423510 Paper 27375923 Paper 27074126 Paper 26083657 Paper 25701691 Paper 25647750 Paper 25444611 Paper 25434394 Paper 25155573 Paper 24807994 Paper 24370654 Paper 24105697 Paper 24067395 Paper 23867580 Paper 23850195 Paper 23576116 Paper 23285256 Paper 23199605 Paper 23140671 Paper 23000025 Paper 22964958 Paper 22926660 Paper 22490435 Paper 22249915 Paper 21930284 Paper 21764858 Paper 21616681 Paper 21392243 Paper 21310252 Paper 21251581 Paper 21229433 Paper 21148807 Paper 21058045 Paper 20706603 Paper 20683742 Paper 20472939 Paper 20472937 Paper 20305128 Paper 20236866 Paper 20216394 Paper 20212264 Paper 20101007 Paper 20056442 Paper 20032809 Paper 19996138 Paper 19950282 Paper 19897069 Paper 19877068 Paper 19779585 Paper 19755477 Paper 19535673 Paper 19470786 Paper 19461530 Paper 19164788 Paper 19064574 Paper 19032994 Paper 19005081 Paper 18987083 Paper 18981032 Paper 18832288 Paper 18779682 Paper 18727924 Paper 18661169 Paper 18580416 Paper 18559416 Paper 18557726 Paper 18483353 Paper 18434216 Paper 18434215 Paper 18350172 Paper 18328959 Paper 18300337 Paper 18166553 Paper 18155964 Paper 18096293 Paper 18037811 Paper 17542008 Paper 17485358 Paper 17481714 Paper 17280575 Paper 17208602 Paper 17201619 Paper 17196294 Paper 16860134 Paper 16341022 Paper 16316301 Paper 16292046

Abstract

The purpose of this protocol is to evaluate neutrophil structure and function. The first approach utilizes micropipet manipulation techniques to study the relationship between chemokine concentration and neutrophil motility responses. The dependence of pseudopod extension on the concentration of fMLP and PAF is characterized. The second investigation utilizes the biointerface probe apparatus to study the compressive (as opposed to tensile) features of the neutrophil cell interface, especially the microvilli and the cortical network that exists under the plasma membrane and to which adhesion receptors are attached. Using the force probe as a nanoscale rheometer, the full course of cell surface contact, indentation, and surface recovery is tested as a function of loading rate.

View original record on NIH RePORTER →