** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** HUMAN NOROVIRUS HAS BEEN REPORTED TO BE THE LEADING CAUSE OF VIRAL GASTROENTERITIS AND FOODBORNE ILLNESS WORLDWIDE. EACH YEAR, NOROVIRUS IS RESPONSIBLE FOR ALMOST 20 MILLION ILLNESSES IN THE UNITED STATES, WHICH CONTRIBUTES NEARLY $2.7-3.9 BILLION IN ECONOMIC LOSSES. HUMAN NOROVIRUS IS EXTREMELY TRANSMISSIBLE AND CAN BE FOUND IN A FULL RANGE OF FOOD PRODUCTS SUCH AS LEAFY VEGETABLES, SOFT FRUITS, AND SHELLFISH. A VARIETY OF ANALYTICAL METHODS HAVE BEEN REPORTED TO DETECT EMERGING VIRUSES, INCLUDING IMMUNOASSAYS (E.G., ELISA), MASS SPECTROMETRY-BASED TESTS (E.G., MALDI-TOF), NUCLEIC ACID-BASED DETECTION (E.G., REVERSE TRANSCRIPTION- QUANTITATIVE POLYMERASE CHAIN REACTION, RT-QPCR), AND SEQUENCING-BASED TECHNIQUES. HOWEVER, THESE DETECTION METHODS CAN PROVIDE RELIABLE, SENSITIVE, AND SPECIFIC DETECTIONONLY IFHUMAN NOROVIRUSES HAVE BEEN CONCENTRATED AND PURIFIED FROM COMPLEX SAMPLES. THE LACK OF PRACTICAL METHODS FOR THE CONCENTRATION AND PURIFICATION OF HUMAN NOROVIRUSES FROM COMPLEX SAMPLES REMAINS A HINDRANCE TO THE SUCCESSFUL DEVELOPMENT OF RAPID DETECTION ASSAYS.