SMALL POULTRY FARMS ARE LOOKING FOR COMPREHENSIVE AND COMPATIBLE INTERVENTIONS THAT SUPPORT PRODUCTION WHILE MEETING DEMAND FOR SAFE &AMP; QUALITY PRODUCTS. HENCE, IMPROVING SUSTAINABILITY FOR SMALL BROILER ENTERPRISES MUST FOCUS NOT ONLY ON BIRD HEALTH AND MEAT SAFETY BUT ALSO ON REDUCING COSTS AND MAXIMIZING PRODUCTIVITY. THUS, THIS INTEGRATED PROPOSAL DESIGNED WITH STAKEHOLDER INPUT AIMS TO DEVELOP EVIDENCE-BASED, MULTI-STAGE RECOMMENDATIONS FOR SMALL ENTERPRISES INCLUDING BREEDER FARMS, GROW-OUT FARMS AND PROCESSORS, ESPECIALLY FOCUSING ON (1) MICROBIAL SAFETY WHILE SUSTAINING BROILER PRODUCTION, (2) PRODUCT QUALITY, AND (3) COST-BENEFIT ANALYSIS. OUR OVERALL GOAL IN THIS PROJECT IS TO DEVELOP A PROBIOTIC- AND POSTBIOTIC-BASED COMPREHENSIVE, FEASIBLE, USER-FRIENDLY AND COST-EFFECTIVE STRATEGY TO PROMOTE BROILER PERFORMANCE, HEALTH AND MEAT SAFETY ALONG THE PRODUCTION PIPELINE. SPECIFICALLY, WE AIM TO I) APPLY PROBIOTICS TO REDUCE SALMONELLA CONTAMINATION IN HATCHING EGGS AND HATCHLINGS WHILE SUPPORTING EMBRYONIC DEVELOPMENT AND HATCHABILITY (PRE-HARVEST), II) SUPPLEMENT PROBIOTICS TO REDUCE SALMONELLA COLONIZATION IN GROW-OUT BIRDS WHILE SUPPORTING PERFORMANCE, REDUCING MORTALITY AND PROMOTING HEALTH (PRE-HARVEST) AND III) EMPLOY POSTBIOTIC WASH TREATMENTS TO REDUCE SALMONELLA LOAD ON POULTRY CARCASSES (POST-HARVEST), AS A MEANS TO REDUCE THE VARIABLE COSTS ASSOCIATED WITH PRODUCTION. IN ADDITION, WE WILL IV) PERFORM COST-BENEFIT ANALYSIS AND V) DEVELOP COMPREHENSIVE EXTENSION/OUTREACH PROGRAMS TO MEET FARMERS' NEEDS AND PROVIDE THEM WITH EFFICIENT TOOLS FOR SUSTAINABLE POULTRY FARMING. ULTIMATELY, WE EXPECT TO HELP PROMOTE THE SUSTAINABILITY, VIABILITY AND COMPETITIVENESS OF SMALL POULTRY PRODUCERS.