** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE GOALOF THIS RESEARCH IS TO ELUCIDATE THE OVERWINTER RECOVERY PHENOMENON OF AN IMPORTANT PLANT PATHOGEN. XYLELLA FASTIDIOSA INFECTS HUNDREDS OF PLANT SPECIES GLOBALLY, INCLUDING A NUMBER OF IMPORTANT CROPS SUCH AS GRAPEVINES, ALMONDS, OLIVES, AND CITRUS. OVERWINTER RECOVERY IS CURRENTLY THE ONLY KNOWN CURE OF PIERCE'S DISEASE OF GRAPEVINES: INFECTED PLANTS RECOVER FROM INFECTIONS AND ARE SYMPTOM- AND PATHOGEN-FREE AFTER EXPOSURE TO COLD WINTER TEMPERATURES. DESPITE ITS IMPORTANCE TO PD ECOLOGY AND MANAGEMENT, VERY LITTLE IS UNDERSTOOD ABOUT THE CLIMATE CONDITIONS THAT INDUCE RECOVERY OR THE BIOLOGICAL MECHANISM THAT KILLS OFFX. FASTIDIOSACELLS. TO CLARIFY THE COLD EXPOSURE NECESSARY TO INDUCE RECOVERY, WE HAVE BEGUN FIELD TRIALS THAT WILL BE INCORPORATED WITH PAST EXPERIMENTAL RESULTS INTO A NEW RECOVERY CLIMATE MODEL. THEN, WE WILL DETERMINE THE SEASONAL TIMING OF RECOVERY BY COMPARING RECOVERY ACROSS GROUPS OF INFECTED STEM SEGMENTS EXCISED AT DIFFERENT STAGES OF DORMANCY. WITH THIS TIMING INFORMATION, WE WILL BE ABLE TO ANALYSE THE TRANSCRIPTOMES OF GRAPEVINES FROM CULTIVARS WITH KNOWN LOW AND HIGH RECOVERY RATES TO DETERMINE GENE EXPRESSION PATTERNS ASSOCIATED WITH RECOVERY.

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