BLACK RASPBERRIES CONTAIN COMPOUNDS LIKE POLYPHENOLS AND ANTHOCYANINS, SHOWING PROMISE IN STRENGTHENING NATURAL KILLER (NK) CELLS VITAL IN FIGHTING CANCER. BY SPECIFICALLY TARGETING NK CELLS, THESE BLACK RASPBERRY COMPOUNDS MIGHT AMPLIFY THEIR FUNCTION, AIDING IN SPOTTING AND ERADICATING EARLY COLON CANCER CELLS. THIS INTERACTION OPENS A POTENTIAL PATH FOR DIETARY STRATEGIES TO ENHANCE THE BODY'S IMMUNE RESPONSE AGAINST COLON CANCER. EMPLOYING BLACK RASPBERRIES TO BOLSTER NK CELL-LED SURVEILLANCE AGAINST THIS CANCER PRESENTS AN INTRIGUING AVENUE IN PREVENTIVE MEASURES, POTENTIALLY REINFORCING THE BODY'S INHERENT DEFENSE MECHANISMS. MOREOVER,WE AIM TO EXPLORE WHETHER SMAD4 IMPACTS IN NK CELLS COLLABORATE OR ADD TO ITS ROLE IN COLONIC EPITHELIAL CELLS DURING COLORECTAL CANCER ADVANCEMENT. THEN, WE WILLASCERTAIN WHETHER BRB-DERIVED GUT BACTERIAL METABOLITES CAN TARGET SMAD4 IN BOTH COLONIC EPITHELIAL CELLS AND NK CELLS.