**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** A BETTER UNDERSTANDING OF NUTRIENT SENSING AND SIGNALINGWILL LED TO NEWINTERVENTIONSTO PREVENT OR DELAY THE ONSET OF METABOLIC DISORDERS AND CHRONIC DISEASES. THIS CONFERENCE PROPOSALDIRECTLY SUPPORTS THE AFRI FOOD SAFETY, NUTRITION, AND HEALTH PROGRAM UNDER THE DIET, NUTRITION AND THE PREVENTION OF CHRONIC DISEASES AREA AND ADDRESSES THE PRIORITY DEVELOP, IMPLEMENT AND EVALUATE INNOVATIVE RESEARCH STRATEGIES TO IMPROVE EATING PATTERNS THAT PREVENT AND CONTROL DIET-RELATED CHRONIC DISEASES AND THE PRIORITY APPROACH PRECISION NUTRITION (A1344).AS A RESULT OF THIS CONFERENCE, NEW APPROACHES TO STUDY DIET AND MEASURE METABOLISM WILL BE DISCUSSED IN AN INTERDISCIPLINARY SETTING, LEADING TO NEW AND DIFFERENT RESEARCH PARTNERSHIPS.NUTRIENT SENSINGAND SIGNALING AREKEY MECHANISMS IN THE DEVELOPMENT OF INSULIN RESISTANCE, METABOLIC SYNDROME, OBESITY, DYSLIPIDEMIA, METABOLIC ASSOCIATED LIVER STEATOSIS, CARDIOVASCULAR DISEASE, CANCER, DIABETES, NEUROLOGICAL DISEASE, SARCOPENIA AND CACHEXIA.THE PROPOSED CONFERENCE WILL BRING TOGETHER SCIENTISTS FROM MULTIPLE DISCIPLINES WITH A COMMON INTEREST IN NUTRIENT SENSING AND THE REGULATION OF METABOLISM AND CELL FUNCTION BY NUTRIENTS. IN THIS WAY, INVESTIGATORS USING MORE INTER-ORGAN AND HOLISTIC APPROACHES CAN SHARE EXPERTISE WITH THOSE WHOSE RESEARCH FOCUSES MORE ON A CELLULAR OR MOLECULAR LEVEL, AND VICE VERSA.ALL OF THE PLANNED CONFERENCE SESSIONS COVER CONCEPTS THAT ARE HIGHLY RELEVANT TO PRECISION/PERSONALIZED NUTRITION AND DIET-RELATED CHRONIC DISEASE. THE LINEUP OF SCIENTIFIC SESSION CHAIRS AND INVITED SPEAKERS INCLUDESRACIAL/ETHNIC MINORITIES, LGBTQ+, GEOGRAPHIC DIVERSITY, AND OTHERGROUPSUNDERREPRESENTED IN SCIENCE. FORMAL AND INFORMAL EVENTS ARE PLANNED TO FACILITATE NEW COLLABORATIONS AND CREATE A CHANGE IN KNOWLEDGE AMONG THE ATTENDEES.