** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE SMALL AND MEDIUM SCALE POULTRY FARMING IS A SIGNIFICANT SUBSET OF THE POULTRY INDUSTRY THAT PLAYS A PIVOTAL ROLE IN HOUSEHOLD POVERTY REDUCTION, COMMUNITY DEVELOPMENT, FOOD SECURITY AND MAINTAINING THE BIODIVERSITY OF THE BIRDS. HOWEVER, SMALL AND MEDIUM SCALE POULTRY FARMING FACES SEVERAL CHALLENGES, INCLUDING REDUCED PRODUCTION EFFICIENCY, DISEASE MANAGEMENT, AND MARKET COMPETITION. THIS MULTI-REGIONAL, MULTI-INSTITUTIONAL, AND MULTI-DISCIPLINARY PROPOSAL INTEGRATING RESEARCH, EXTENSION AND EDUCATION AIMS TO IMPROVE POULTRY FARMING PRACTICES BY INTRODUCING AN ECONOMICAL, USER-FRIENDLY, AND SCALABLE STRATEGY OF INCORPORATING OXYGEN NANOBUBBLES INTO POULTRY DRINKING WATER. THE EFFECT OF ENHANCED OXYGEN SUPPLEMENTATION VIA DRINKING WATER WILL BE STUDIED IN FOUR BROAD RESEARCH AREA NAMELY (1) GUT HEALTH AND PRODUCTION EFFICIENCY, (2) DISEASE MANAGEMENT FOCUSING ON NECROTIC ENTERITIS, (3) CARCASS/MEAT QUALITY, AND (4) COST-BENEFIT ANALYSIS OF THE INVENTION. PROJECT RESULTS WILL BE DISSEMINATED TO SCIENTIFIC GROUPS, FARMERS, STAKEHOLDERS AND COMMUNITY THROUGH WORKSHOPS, SOCIAL MEDIA, WEBINARS AND CONFERENCE PRESENTATIONS. MOREOVER, RESEARCH FINDINGS FROM THE GRANT WILL BE INCLUDED IN CURRENT UNIVERSITY CURRICULUM TO TRAIN THE NEXT GENERATION OF THE WORKFORCE AFTER THE LIFE OF THE GRANT. THE PROGRAM STAFF CONSISTS OF A COMBINATION OF YOUNG, MID-CAREER, AND SENIOR SCIENTISTS WITH EXPERTISE IN POULTRY PRODUCTION, DISEASE MANAGEMENT, MICROBIOLOGY, MEAT QUALITY, POULTRY ECONOMICS, EXTENSION AND EDUCATION. SUCCESSFUL COMPLETION OF THIS PROJECT WILL TRANSLATE INTO INCREASED SUSTAINABILITY AND PROFITABILITY FOR SMALL AND MEDIUM SCALE POULTRY FARMERS.